DeMoss played football as a quarterback at Purdue from 1945 to 1948. He helped the Boilermakers win their first four games and move into the national rankings at No. 9. The next week, he led the Boilermakers into Ohio Stadium, where they routed the #4 team in the country, 35-13 He was then selected in the second round of the 1949 NFL Draft by the New York Bulldogs, for whom he played in 1949. DeMoss was selected again in the 22nd round of the 1950 NFL Draft by the New York Giants, but retired from playing to become an assistant football coach at Purdue.
Assistant coach
For 20 years, beginning in 1950, DeMoss was an assistant football coach where he was credited with developing Purdue's reputation as the 'cradle of quarterbacks,' having recruited and coached the likes of Dale Samuels, Len Dawson, Bernie Allen, Bob Griese, Mike Phipps and Gary Danielson. As assistant athletics director, DeMoss oversaw the baseball, men's cross country, men's golf, men's swimming and diving, men's tennis, men's track and field, and wrestling programs.
In 1970, DeMoss replaced Jack Mollenkopf as head coach. Two days after Mollenkopf announced his retirement, DeMoss was named his successor, becoming the third and most-recent Purdue alum to serve as head coach. DeMoss inherited a Purdue squad who was loaded at the running back position with Stan Brown, and Otis Armstrong, but the team struggled to find consistency out of its quarterback position. DeMoss resigned following the 1972 season, citing his desire to be with his family more as his reason for stepping down. DeMoss compiled a career college football record of 13–18. In DeMoss' three seasons as head coach, the Boilermakers posted an 11-12 Big Ten mark. On October 3, 1970, Purdue upset third-ranked Stanford University with a 26-14 scoring on the road, earning DeMoss Coach of the Week laurels by United Press International. DeMoss resigned as coach on December 3, 1972, making him the last quarterback to coach the Boilermakers until current head coach Jeff Brohm. After his stint as Purdue's head football coach, DeMoss remained an assistant athletics director at Purdue until his retirement in 1992. In September 2008 the Purdue athletics department honored Bob DeMoss with the unveiling of a placard bearing his name for the offensive staff room in the football offices of the Mollenkopf Athletic Center.
Honors
DeMoss was inducted into Purdue's Intercollegiate Athletes Hall of Fame as part of the Class of 1999.
