Karbo studied at the University for Development Studies, receiving a bachelor's degree in Integrated Development Studies in 2005. As a student, Karbo distinguished himself as a student leader and rose through the ranks to become the Central Student Representative Council President of the University for Development Studies in 2004. Before then, he was President of TESCON, Navrongo Campus. Karbo also served on the Central Committees of both the National Union of Ghana Students and the University Students Association of Ghana. His performance in these roles earned him an appointment on the Upper West Regional Campaign Team ahead of the NPP 2004 general elections. In 2006, he graduated with a Masters in Economic Policy and International Business from University of Birmingham. In 2007, at the behest of then flag bearer of the New Patriotic Party, Nana Akufo-Addo Karbo returned to Ghana to pursue active politics.
Party politics
In March 2008, Karbo was appointed a member of the national research team of the New Patriotic Party. He was promoted in December 2008 to be the Campaign Coordinator for the Vice Presidential candidate of the New Patriotic Party Dr. Mahamudu Bawumia. After the defeat of the Party in the 2008 elections, Karbo returned to the Party ’s office and served as a key member of the Party's communication unit. In 2010, Karbo was elected National Youth Organizer of the Party. Karbo held this role until 2012 when he resigned to pursue his bid of becoming the Party's Parliamentary candidate for the newly created Lawra Constituency in keeping with the Party's policy. Unsuccessful in his attempt, Karbo returned to serve as a Deputy Communications Director of the New Patriotic Party and Spokesperson for the Vice Presidential Candidate.
Member of Parliament
Abayifaa Karbo was first elected to the Parliament of Ghana on the ticket of the NPP in December 2016 after defeating the incumbent Sampson Abu and Upper West Regional Minister Bede Ziedeng. Prior to the elections, many had doubted his chances of success since the ruling National Democratic Congress had held the seat for eight years. Few days after his swearing in as MP, it was largely speculated in the Ghanaian media that he was going to be appointed a deputy Minister.
Deputy Minister
In April 2017, Karbo was appointed as Deputy Minister for Roads and Highways. As Deputy Minister, Karbo chaired the working committee on the Sinohydro deal at the Ministry for Road and Highways, the biggest infrastructure barter in the history of Ghana. Karbo has persistently argued for open partnerships as a way of developing Ghana's road infrastructure.
Personal life and interests
Karbo is married to Awenlue Kante-Karbo and has three children. He is a Christian, born and raised a Catholic and is a devout member of the Lawra Parish of the Catholic Church. Besides politics, Karbo actively pursues farming and likes to take advantage of opportunities to engage in communal farming activities with his constituents and thus further consolidating his persona as a grassroots politician. Anthony Karbo is generally viewed as pro-African and pro-poor in his beliefs. While not rejecting foreign cooperation and assistance, Karbo has often called for economic partnerships which directly benefits the ordinary citizens of African States.
It was reported in 2017 that increasing demand for dog meat has led politician Anthony Karbo to propose dog meat factories in three northern regions of Ghana.