Along with Akkamma Cherian and Pattom Thanu Pillai, Mascarene was one of the leaders of the movements for independence and integration of the Princely States within the Indian nation. In February 1938, when the political party Travancore State Congress was formed, she became one of the first women to join. The party goal was to establish a responsible government for Travancore and it was led by Pattom Thanu Pillai as president under whom served K. T. Thomas and P. S. Nataraja Pillai, secretaries, and M. R. Madhava Warrier, treasurer. Macsarene was appointed to the working committee and also served on the party's publicity committee. One of the first acts of the working committee was to send a memorandum to the MajarajaSree Chithira Thirunal to demand the termination of the appointment of Sir C. P. Ramaswami Iyer and establish an enquiry into his administration, appointments, and financial affairs in his role as dewan. Iyer and his supporters retaliated for the attack on his administration. In a statewide propaganda tour undertaken with party president Pillai, Mascarene was outspoken in her criticism of the level of participation allowed in the legislature, of the dewan, and the government. Her statements led to assault by a police officer as well as her home being broken into and her property being stolen. She published an account of the incident, angering the police. Iyer spoke to the Maharaja against her, alleging that Mascarene was making speeches defaming the government and encouraging non-payment of taxes. The police commissioner also reported that she was dangerous and fomenting discontent. Her activism led to numerous arrests and imprisonments for various periods from 1939-1947. In 1938 and 1939, Mascarene served on the Economic Development Board of the Travancore government. During her time in the state legislature, she became a powerful speaker and enjoyed policymaking. In 1942, Mascarene joined the Quit India Movement and two years later was elected as secretary of the Travancore State Congress. On 21 February 1946Mahatma Gandhi wrote to Mascarene regarding a speech she had delivered in Bombay, "Even otherwise, I know that you have no control over your tongue and when you stand up to speak, you blab anything that comes to your mind. This speech also is quite a specimen, if the newspaper report is correct. I have sent the report to Bhai Thanu Pillai. You can read it. Such indiscreet talk can do good neither to you nor to the poor people of Travancore. Besides, by your act you put the whole fair sex to shame". Gandhi also wrote to a colleague in the state congress, Pillai hoping to relieve Mascarene of her ministerial role in the government.