Afadin
Afadin is a protein that in humans is encoded by the AFDN gene.Function
Afadin is a Ras target that regulates cell–cell adhesions downstream of Ras activation. It is fused with MLL in leukemias caused by t translocations.Interactions
Afadin has been shown to interact with:
- BCR gene,
- EPHB3,
- F11 receptor,
- HRAS and
- LMO2,
- PVRL1,
- PVRL3,
- Profilin 1,
- RAP1A,
- RAP1GAP,
- SORBS1,
- SSX2IP,
- Tight junction protein 1, and
- USP9X.
