The race was run on Sunday, August 23, 2015. The scheduled distance was, which required 200 laps around the triangular oval in length.
Recap
The pole position was won by Hélio Castroneves of Team Penske, driving the No. 3 car. Penske Chevrolets qualified in the first three positions, with Castroneves' teammate Simon Pagenaud starting alongside him in the No. 22 and defending series champion Will Power behind him in position three. Karam, driving a Chevrolet for Chip Ganassi Racing, qualified 20th, with Wilson seventh and Hunter-Reay eighth. Overall, twenty-four drivers qualified for the race. Castroneves would eventually crash out of the event, finishing sixteenth. Wilson was scored in fifteenth, with Karam one position in front of him. The highest finishing of the Penske cars was the No. 2 of series points leader Juan Pablo Montoya, as he finished in third to receive a spot on the podium. Josef Newgarden, driving the No. 67 Chevrolet for CFH Racing, took the other position on the podium by way of his second-place finish and finished with a race-high 47 laps led. He was followed by Gabby Chaves, who led 31 laps in the No. 98 Honda for Bryan Herta Autosport, and Pagenaud, who led 30 laps. Hunter-Reay, Castroneves, and Tony Kanaan each led more than 20 laps. There were 12 caution periods for 74 laps, and the race ended under the yellow flag. Eleven cars were running at the finish, with each being on the lead lap except for Pippa Mann, whose No. 18 Dale Coyne Racing Honda was running in thirteenth place fifteen laps down.
On lap 180 of the event, Karam was leading when he lost control of his car in turn one and made contact with the wall. The impact tore away most of the front end of Karam's car and he slid to a stop just past the exit to Turn 1. The nose cone of the Chevrolet came off with such force that it was bouncing along on the track as the drivers drove past. When Wilson, running fourteenth, drove by the scene, Karam's nose cone struck him in the head and knocked him unconscious. Wilson's No. 25 Honda lost control and veered off track, hitting the inner wall just past Turn 1 and continuing to slide up the track. Karam, though shaken up, was able to exit his car with no major injuries. Wilson, however, was unresponsive when the track safety crew arrived at his machine and he had to be extricated from the car. A medivac helicopter was called for and transported Wilson to Lehigh Valley Hospital in nearby Allentown. He was reported to be in a coma with a severe head injury and was listed in critical condition. At approximately 21:00 local time on August 24, 2015, a press conference at Indianapolis Motor Speedway announced that Wilson had died from his injuries at the age of 37. Wilson was the first IndyCar driver to lose his life since Dan Wheldon's fatal accident at the 2011 IZOD IndyCar World Championship in Las Vegas. His death was the second such occurrence in the world of open-wheel racing in 2015, following the death of Marussia F1 driver Jules Bianchinine months after suffering a diffuse axonal injury in a crash at the 2014 Japanese Grand Prix.