The draw was held on 28 August 2015, 13:00 CEST, at the Grimaldi Forum in Monaco. The 48 teams were drawn into twelve groups of four, with the restriction that teams from the same association could not be drawn against each other. For the draw, the teams were seeded into four pots based on their 2015 UEFA club coefficients. Moreover, the draw was controlled for teams from the same association in order to split the teams evenly into the two sets of groups for maximum television coverage. The fixtures were decided after the draw. On each matchday, six groups play their matches at 19:00 CEST/CET, while the other six groups play their matches at 21:05 CEST/CET, with the two sets of groups alternating between each matchday. There are other restrictions: for example, teams from the same city in general do not play at home on the same matchday, and teams in certain countries do not play at home on the last matchday. On 17 July 2014, the UEFA emergency panel ruled that Ukrainian and Russian clubs would not be drawn against each other "until further notice" due to the political unrest between the countries. Therefore, Ukrainian club Dnipro Dnipropetrovsk and Russian clubs Rubin Kazan, Lokomotiv Moscow and Krasnodar could not be drawn into the same group.
Teams
Below are the 48 teams which qualified for the group stage, grouped by their seeding pot. They include 16 teams which enter in this stage, the 22 winners of the play-off round, and the 10 losers of the Champions League play-off round.
Key to colours
Group winners and runners-up advance to the round of 32
;Notes
Format
In each group, teams play against each other home-and-away in a round-robin format. The group winners and runners-up advance to the round of 32, where they are joined by the eight third-placed teams from the Champions League group stage.
Tiebreakers
The teams are ranked according to points. If two or more teams are equal on points on completion of the group matches, the following criteria are applied in the order given to determine the rankings :
higher number of points obtained in the group matches played among the teams in question;
superior goal difference from the group matches played among the teams in question;
higher number of goals scored in the group matches played among the teams in question;
if, after having applied criteria 1 to 4, teams still have an equal ranking, criteria 1 to 4 are reapplied exclusively to the matches between the teams in question to determine their final rankings. If this procedure does not lead to a decision, criteria 6 to 12 apply;
superior goal difference in all group matches;
higher number of goals scored in all group matches;
higher number of away goals scored in all group matches;
higher number of wins in all group matches;
higher number of away wins in all group matches;
lower disciplinary points total based only on yellow and red cards received in all group matches ;
