1880–81 in Scottish football
The 1880–81 season was the eighth season of competitive football in Scotland.
Scottish Cup
| Winner | Score | Runner-up |
| Queen's Park | 3–1 | Dumbarton |
County honours
| Competition | Winner | Score | Runner-up |
| Ayrshire Cup | Lugar Boswell | 5–0 | Annbank |
| Edinburgh FA Cup | Hibernian | 1–0* | St Bernard's |
| Lanarkshire Cup | Thistle | 3–2 | Shotts |
| Renfrewshire Cup | Arthurlie | 3–1 | St Mirren |
- replay
Other honours
- replayScotland national team
| Date | Venue | Opponents | Competition | Scotland scorers | |
| 12 March 1881 | Kennington Oval, London | 6–1 | Friendly | John Smith, George Ker, David Hill | |
| 14 March 1881 | Acton Park, Wrexham | 5–1 | Friendly | George Ker, Henry McNeil, two own goals |