1654

January–June

• January 11 - A Spanish army is defeated by local Mapuche-Huilliches as it tries to cross Bueno River in Southern Chile.
• March 12-13 - The Treaty of Pereyaslav is concluded in the city of Pereyaslav, during the meeting between the Cossacks of the Zaporozhian Host and Tsar Alexey I of Russia, following the end to the Khmelnytsky Uprising in Ukraine, which had started in 1648 and had resulted in the massacre of many thousands of Jews.
• April 5 - The Treaty of Westminster, ending the First Anglo-Dutch War, is signed.
• April 11 - A commercial treaty between England and Sweden is signed.
• April 12 - Oliver Cromwell creates a union between England and Scotland, with Scottish representation in the Parliament of England.
• May 8 - Otto von Guericke demonstrates the power of atmospheric pressure and the effectiveness of his vacuum pump, using the Magdeburg hemispheres, before Ferdinand III, Holy Roman Emperor, and the Imperial Diet in Regensburg.
• June 3 - Louis XIV of France is crowned at Reims.
• June 16 - Charles X Gustav succeeds his cousin Christina on the Swedish throne. After her abdication on the same day, Christina, now the former reigning queen of a Protestant nation, secretly converts to Catholicism.

  July–December

• July - The Russian Army seizes Smolensk and the Thirteen Years' War starts between Russia and Poland over Ukraine.
• July 10 - Peter Vowell and John Gerard are executed in London for plotting to assassinate Oliver Cromwell.
• July 10 - Don Pantaleon, brother of the Portuguese ambassador, is executed after the death of an innocent man following a fracas at the exchange in Exeter.
• August - Oliver Cromwell launches the Western Design, an English expedition to the Caribbean to counter Spanish commercial interests, effectively beginning the Anglo-Spanish War. The fleet leaves Portsmouth in late December.
• August 22 - Jewish arrival in New Amsterdam: 23 Sephardic Jews arrive as refugees from Brazil and settle in New Amsterdam, forming the nucleus of what will be the second largest urban Jewish community in history, that of New York City, and of Congregation Shearith Israel, the first synagogue in North America.
• September 3 - In England, the First Protectorate Parliament assembles.
• September 12 - Oliver Cromwell orders the exclusion of 120 members of Parliament who are hostile to him.
• October 12 - The Delft Explosion, in the arsenal, devastates the city in the Netherlands, killing more than 100, among whom is Carel Fabritius, the most promising student of Rembrandt.
• October 31 - Ferdinand Maria, Elector of Bavaria, is crowned. His absolutist style of leadership becomes a benchmark for the rest of Germany.
• November 23 - French mathematician, scientist and religious philosopher Blaise Pascal experiences an intense mystical vision that marks him for life.

  Births

• January 5 - Henry Poley, English politician
• January 10 - Joshua Barnes, English scholar
• January 10 - Giovanni Maria Gabrielli, Italian Catholic cardinal
• January 20 - Michiel de Swaen, Flemish poet
• January 22 - Richard Blackmore, English physician and writer
• February 3 - Pietro Antonio Fiocco, Italian composer
• February 12 - Dorothea Maria of Saxe-Gotha-Altenburg, German princess
• February 15 - Tsarevich Alexei Alexeyevich of Russia, son and heir of Tsar Alexis of Russia
• February 22 - Elizabeth Monck, Duchess of Albemarle
• March 6 - Andreas Acoluthus, German scholar
• March 9 - Robert Leke, 3rd Earl of Scarsdale, English earl, politician
• March 10 - Giuseppe Bartolomeo Chiari, Italian painter
• March 12 - Charles Egerton, English politician
• March 12 - Giuseppe Passeri, Italian painter
• March 12 - Jan Hoogsaat, Dutch painter
• March 12 - Frederick Augustus, Duke of Württemberg-Neuenstadt
• March 16 - Andreas Acoluthus, German orientalist
• March 28 - Sophie Amalie Moth, royal mistress of King Christian V of Denmark
• March 28 - Joan de Cabanas, Occitan language writer
• March 31 - Lorenzo Cozza, Italian Catholic cardinal
• April 8 - Peder Krog, Lutheran bishop
• April 20 - John Backwell, English politician
• April 27 - Charles Blount, English deist and philosopher
• April 30 - Robert Digby, 3rd Baron Digby, English peer and Member of Parliament
• May 4 - Kangxi Emperor of Qing China
• May 13 - Thomas Lennard, 1st Earl of Sussex, English cricketer
• May 23 - Nicodemus Tessin the Younger, Swedish architect
• May 28 - Thomas Handcock, Irish politician
• June 4 - Jean-François Gerbillon, French Jesuit missionary active in China
• June 23 - Grzegorz Antoni Ogiński, Polish-Lithuanian noble
• June 23 - Richard Onslow, 1st Baron Onslow, English politician
• June 23 - Sophia of Saxe-Weissenfels, Princess of Anhalt-Zerbst
• June 24 - Thomas Fuller, British physician
• June 30 - Thomas Rice, Massachusetts legislator
• July 1 - Louis Joseph, Duke of Vendôme, French military commander
• July 7 - Aoyama Tadashige, Japanese daimyō
• July 9 - Emperor Reigen of Japan
• July 24 - Henry Herbert, 1st Baron Herbert of Chirbury, English politician
• July 25 - Agostino Steffani, Italian ecclesiastic, diplomat and composer
• August 3 - Charles I, Landgrave of Hesse-Kassel
• August 4 - Thomas Brodrick, Irish politician
• August 10 - Bernard Nieuwentyt, Dutch mathematician and philosopher
• August 15 - John Joseph of the Cross, Italian saint
• August 23 - Anthony Morris, American politician
• September 7 - François Pagi, French Franciscan historian of the Catholic Church
• September 11 - William Handcock, Irish politician
• September 16 - Philippe Avril, French Jesuit explorer
• October 6 - Johan Peringskiöld, Swedish antiquarian
• October 18 - John Frederick, Margrave of Brandenburg-Ansbach
• October 23 - Johann Bernhard Staudt, Austrian composer
• October 26 - Giovanni Maria Lancisi, Italian physician
• November 5 - Christian Liebe, German composer
• November 7 - Sir John Delaval, 3rd Baronet, English politician
• November 9 - Christoph Weigel the Elder, German engraver
• November 23 - George Watson, a Scottish accountant and the founder of George Watson's College in Edinburgh
• November 23 - Jan van Kessel the Younger, Flemish painter in Spain
• November 27 - Friedrich von Canitz, German poet and diplomat
• December 1 - John Hartstonge, Irish bishop
• December 10 - Giovanni Gioseffo dal Sole, Italian painter
• December 13 - Robert Livingston the Elder, New York colonial official
• December 15 - Johann Theodor Jablonski, German lexicographer
• December 22 - Edmond Martène, French Benedictine historian and liturgist
• December 27 - Jacob Bernoulli, Swiss mathematician and scientist
• December 30 - Archduchess Maria Anna Josepha of Austria, youngest surviving daughter of Ferdinand III
• probable - Eleanor Glanville, English entomologist

  Deaths

• January 10 - Nicholas Culpeper, English botanist
• January 17 - Paulus Potter, Dutch painter
• February 6 - Francesco Mochi, Italian early-Baroque sculptor
• February 8 - Luca Ferrari, Italian painter
• February 18 - Jean-Louis Guez de Balzac, French writer
• March 7 - Ernest Gottlieb, Prince of Anhalt-Plötzkau
• March 14 - Jan van Balen, Flemish painter
• March 15 - Jean Guiton, French Huguenot ship owner
• March 19 - Matsudaira Norinaga, Japanese daimyō
• March 22 - Théodore de Mayerne, Swiss physician
• March 24 - Samuel Scheidt, German composer
• March 30 - Aleksander Ludwik Radziwiłł, Polish noble
• April 5 - Jacobus Trigland, Dutch theologian
• May 18 - Muhammad Qadiri, Punjabi founder of the Naushahia branch of the Qadri Order
• May 21 - Elizabeth Poole, English settler in Plymouth Colony
• May 31 - Hippolytus Guarinonius, Italian physician and polymath
• June 10 - Alessandro Algardi, Italian sculptor and architect
• June 14 - Dániel Esterházy, Hungarian noble
• June 27 - Johannes Valentinus Andreae, German theologian
• July 9 - Ferdinand IV, King of the Romans
• July 23 - Orazio Grassi, Italian Jesuit priest, architect and scientist
• August 12 - Cornelius Haga, Dutch diplomat
• August 19 - Yom-Tov Lipmann Heller, Bohemian rabbi and liturgical poet
• August 28 - Axel Oxenstierna, Lord High Chancellor of Sweden since 1612
• August 29 - Wouter van Twiller, Director-General of New Netherland from 1633 until 1638
• August 31 - Ole Worm, Danish physician and antiquary
• September 6 - Christian I, Count Palatine of Birkenfeld-Bischweiler
• September 8 - Peter Claver, Spanish Jesuit priest
• September 27 - Louis, Duke of Joyeuse, younger son of Charles
• September 29 - George John II, Count Palatine of Lützelstein-Guttenberg
• October 12 - Carel Fabritius, Dutch artist
• October 16 - Hercule, Duke of Montbazon
• October 20 - Thomas Jervoise, English politician
• October 30 - Emperor Go-Kōmyō of Japan
• November 27 - Pieter Meulener, Flemish Baroque painter
• November 26 - Giambattista Altieri, Italian Catholic cardinal
• November 30
• * John Selden, English jurist
• * William Habington, English poet
• December 1 - Jakov Mikalja, Italian linguist and lexicographer
• December 4 - Sir Christopher Yelverton, 1st Baronet, English politician
• December 5 - Jean François Sarrazin, French writer
• date unknown - Elizabeth Isham, English diarist